Ryan Reynolds Wade Wilson / Deadpool / Juggernaut (voice) / Himself Josh Brolin Nathan Summers / Cable Morena Baccarin Vanessa Carlysle Julian Dennison Russell Collins / Firefist Zazie Beetz Neena Thurman / Domino T. J. Miller Jack Hammer / Weasel Leslie Uggams Blind Al Karan Soni Dopinder Brianna Hildebrand Ellie Phimister / Negasonic Teenage Warhead Jack Kesy Black Tom Cassidy Eddie Marsan Headmaster Shioli Kutsuna Yukio / Pinkie Pie Stefan Kapičić Piotr Rasputin / Colossus (voice) Randal Reeder Buck Nikolai Witschl Head Orderly Frye Thayr Harris Sergei Valishnikov Rob Delaney Peter Lewis Tan Gaveedra-Seven / Shatterstar Bill Skarsgård Axel Cluney / Zeitgeist Terry Crews Jesse Aaronson / Bedlam Brad Pitt Telford Porter / Vanisher Paul Wu Hong Kong Boss Robert Maillet Sluggo Alan Tudyk Luke, Redneck #1 Matt Damon Redneck #2 Michasha Armstrong SWAT Captain (School) Joe Doserro Bus Driver Hayley Sales Cable's Wife Islie Hirvonen Hope, Cable's Daughter Jagua Arneja Tree Trimmer #1 Gerry South Tree Trimmer #2 Sala Baker Older Russell Collins / Firefist Sonia Sunger News Reporter (Irene) Sam Hargrave DMC Guard (uncredited) Nicholas Hoult Beast (uncredited) Tye Sheridan Cyclops (uncredited) Alexandra Shipp Storm (uncredited) Hugh Jackman Wolverine / Logan (archive footage)