Ryan Reynolds Wade Wilson / Deadpool / Nicepool Hugh Jackman Logan / Wolverine Emma Corrin Cassandra Nova Matthew Macfadyen Mr. Paradox Dafne Keen Laura / X-23 Jon Favreau Happy Hogan Morena Baccarin Vanessa Rob Delaney Peter Leslie Uggams Blind Al Jennifer Garner Elektra Wesley Snipes Blade Channing Tatum Gambit Chris Evans Johnny Storm Henry Cavill The Cavillrine Wunmi Mosaku B-15 Aaron Stanford Pyro Tyler Mane Sabretooth Karan Soni Dopinder Brianna Hildebrand Negasonic Teenage Warhead Shioli Kutsuna Yukio Stefan Kapicic Colossus (voice) Randal Reeder Buck Lewis Tan Shatterstar Nick Pauley Dancepool Sonita Henry Mrs. Chipman Ryan McKen Mr. Chipman Leemore Marrett Jr. Minuteman Leader James Dryden TVA Tech Ollie Palmer Bar Patron Greg Hemphill Seedy Bartender Aaron W Reed Juggernaut Rob McElhenney TVA Soldier Ed Kear Outpost Tech Paul G. Raymond TVA Office Agent Blake Lively Ladypool (voice) Nathan Fillion Headpool (voice) Matthew McConaughey Cowboypool (voice) Chris Hemsworth Thor Odinson (archive footage) (uncredited)